The show premiered on January 31, 1999 and originally ended on February 14, 2002.
After the overwhelming success of DVD sales and cable ratings on Adult Swim, FOX decided to revive the program, and it began airing again on May 1, 2005.
Peter must embark on a vision quest to prove he has Native American blood to save the day.
Peter persuades Brian to swallow his pride and enter a dog show to win some extra cash.
They also discover that they have a half-witch sister named Paige and she joins them in the fight against evil.
But when Peter takes a wrong turn, they end up at a Native American Casino where Lois hits the slot machine once too often.
As the show goes on the sisters learn of more powerful things they can do and more magic they can create.
Each episode features the sisters defeating another villain that was sent to take over the world.
Lois becomes fast friends with Bonnie, Meg tries to pick up on son Kevin and Peter is forced to invite Joe to play on his company baseball team.
But when Joe shows up to the game in a wheelchair and wins the crowd's hearts with his slick maneuvers and winning plays, Peter decides he wants to be a hero too.