Already at war with other Iroquoian tribes, the Wyandots begin to move west.1541 - May 8; Soto reaches the Mississippi River, having marched overland from the Floridas.
The brutal behavior of the Spanish has a devastating effect on the tribes of the southeast; perhaps coincidently, Mississippian culture enters a rapid decline.c.
They reach the Mississippi on June 17, and the mouth of the Arkansas a month later, where they turn back after learning there are Spanish in the area of the present New Orleans.1680 - August 21; Pueblo Indians take possession of Santa Fe after driving out the Spanish.August 15; a Spanish military expedition from Santa Fe and their Apache allies are defeated by the Pawnee and their French allies near the principal Pawnee village at the forks of the Platte in present Nebraska. 1730 - While retaining their settlements in the Detroit area, many Wyandots migrate southward and settle on the south shore of Lake Erie.They gradually assume sovereignty over all the Ohio country between the Great Lakes and the Miami River.Petun and Huron refugees leave Ontario, and spend the winter of 1649-50 on Mackinac Island.c.1650 - First French contact with the Shawnee in Tennessee, where they have drifted from Ohio. The Five Nations temporarily control all the lands on either side of Lake Erie and Lake Ontario.1673 - In May, Father Marquette and Louis Joliet set out from St.